Meeting Banner
Abstract #4210

Neuronal energy metabolism in the mouse brain measured by 1H-[13C] MRS at 14.1T under [3-13C]-Lactate infusion: a feasibility study

Bernard Lanz1, Lijing Xin2, Nicolas Kunz2, and Hongxia Lei2,3

1Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Faculty of Medicine, University of Geneva, Geneva, Switzerland

In this study, the feasibility of studying neuronal energy metabolism in the mouse brain in vivo under [3-13C]-Lactate infusion, measured by 1H-[13C] MRS at high magnetic field was evaluated. Brain tissue [3-13C]-Lactate enrichment and the turnover of its metabolic products were measured dynamically. Glutamate and glutamine C4 as well as glutamate+glutamine C3 were used as input to a one-compartment metabolic model of the neuronal TCA cycle and glutamate-glutamine cycle, enabling a comparison with previously reported values of metabolic fluxes in the mouse brain under infusion of other labeled substrates.

This abstract and the presentation materials are available to members only; a login is required.

Join Here