Abstract #4210

Neuronal energy metabolism in the mouse brain measured by 1H-[13C] MRS at 14.1T under [3-13C]-Lactate infusion: a feasibility study

Bernard Lanz¹, Lijing Xin², Nicolas Kunz², and Hongxia Lei^2,3

¹Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ³Faculty of Medicine, University of Geneva, Geneva, Switzerland

In this study, the feasibility of studying neuronal energy metabolism in the mouse brain in vivo under [3-¹³C]-Lactate infusion, measured by ¹H-[¹³C] MRS at high magnetic field was evaluated. Brain tissue [3-¹³C]-Lactate enrichment and the turnover of its metabolic products were measured dynamically. Glutamate and glutamine C4 as well as glutamate+glutamine C3 were used as input to a one-compartment metabolic model of the neuronal TCA cycle and glutamate-glutamine cycle, enabling a comparison with previously reported values of metabolic fluxes in the mouse brain under infusion of other labeled substrates.

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