Abstract #4229

Characterization of downfield spectra using iRE-MRS

Sonia Isabel Goncalves¹, Clémence Ligneul¹, and Noam Shemesh¹

¹Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon PT, Lisbon, Portugal

MRS allows non-invasive in-vivo exploration of tissue metabolism. However,about half of the proton spectrum (downfield of water) has been nearly ignored over the decades of MRS application due to water suppression.We show that ISIS-based Relaxation Enhanced MRS (iRE-MRS) which uses frequency selective excitation and ISIS localization offers short echo times and enhances exchange-broadened resonances.We measure the T1s and calculate signal decay due to T2 relaxation and find that downfield peaks show a signal decrease of more than 50% when increasing TE from 5 to only 16 ms.Calculated T1 values are in the range of 1.55-1.75 s.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.