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Abstract #4229

Characterization of downfield spectra using iRE-MRS

Sonia Isabel Goncalves1, Clémence Ligneul1, and Noam Shemesh1

1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon PT, Lisbon, Portugal

MRS allows non-invasive in-vivo exploration of tissue metabolism. However,about half of the proton spectrum (downfield of water) has been nearly ignored over the decades of MRS application due to water suppression.We show that ISIS-based Relaxation Enhanced MRS (iRE-MRS) which uses frequency selective excitation and ISIS localization offers short echo times and enhances exchange-broadened resonances.We measure the T1s and calculate signal decay due to T2 relaxation and find that downfield peaks show a signal decrease of more than 50% when increasing TE from 5 to only 16 ms.Calculated T1 values are in the range of 1.55-1.75 s.

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