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Abstract #4280

Partial Fourier Reconstruction of Hyperpolarized 13C EPI in the Human Brain

Benjamin J. Geraghty1,2, Casey Y. Lee1,2, Albert P. Chen3, Nadia Bragagnolo1,2, William J. Perks4, Hany Soliman5, and Charles H. Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada, 4Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Asymmetric in-plane k-space sampling of EPI can reduce the minimum achievable TE in hyperpolarized 13C with spectral-spatial radio frequency pulses, thereby reducing T2* weighting and signal-losses. Partial Fourier image reconstruction exploits the approximate Hermitian symmetry of k-space data and can be applied to asymmetric data sets to synthesize unmeasured data. Here we present the results of applying partial Fourier image reconstruction from hyperpolarized [1-13C]pyruvate scans in human brain. A quantitative evaluation of image sharpness using no-reference image quality assessment agreed with a perceived improvement in contrast and resolution.

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