Abstract #4280

Partial Fourier Reconstruction of Hyperpolarized 13C EPI in the Human Brain

Benjamin J. Geraghty^1,2, Casey Y. Lee^1,2, Albert P. Chen³, Nadia Bragagnolo^1,2, William J. Perks⁴, Hany Soliman⁵, and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada, ⁴Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Asymmetric in-plane k-space sampling of EPI can reduce the minimum achievable TE in hyperpolarized ¹³C with spectral-spatial radio frequency pulses, thereby reducing T2* weighting and signal-losses. Partial Fourier image reconstruction exploits the approximate Hermitian symmetry of k-space data and can be applied to asymmetric data sets to synthesize unmeasured data. Here we present the results of applying partial Fourier image reconstruction from hyperpolarized [1-¹³C]pyruvate scans in human brain. A quantitative evaluation of image sharpness using no-reference image quality assessment agreed with a perceived improvement in contrast and resolution.

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