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Abstract #4281

Limits of Kinetic Modeling for Myocardial Infarction and Border Zone Detection Using Hyperpolarized 13C Magnetic Resonance Imaging

Julia Traechtler1, Maximilian Fuetterer1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Kinetic modeling of hyperpolarized [1-13C]-pyruvate imaging allows quantification of cardiac metabolism. In this work, SNR is identified as a limiting factor for the detection of focal lesions and border zones with hyperpolarized 13C imaging under typical in-vivo conditions. Moreover, limits are determined with respect to SNR and resolution requirements. Based on calculated maps of kinetic conversion rates, infarcted areas with transmuralities ≥ 33% are distinguishable from remote myocardium even at a modest resolution of 10mm, while altered metabolism in the border zone (area-at-risk) is not detectable, even at higher resolutions of 5mm.

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