Kinetic modeling of hyperpolarized [1-13C]-pyruvate imaging allows quantification of cardiac metabolism. In this work, SNR is identified as a limiting factor for the detection of focal lesions and border zones with hyperpolarized 13C imaging under typical in-vivo conditions. Moreover, limits are determined with respect to SNR and resolution requirements. Based on calculated maps of kinetic conversion rates, infarcted areas with transmuralities ≥ 33% are distinguishable from remote myocardium even at a modest resolution of 10mm, while altered metabolism in the border zone (area-at-risk) is not detectable, even at higher resolutions of 5mm.
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