T2 is a promising MR-based biomarkers for early diagnosis of osteoarthritis (OA). Studies have shown that quantitative DESS (qDESS) is capable of performing simultaneous knee morphometry and T2 relaxometry. In this study, we investigate the cross-vendor reproducibility of knee T2 relaxometry using qDESS. By comparing measured cartilage and meniscus T2 values in volunteers scanned on both Philips 3T and GE 3T scanners, we show that qDESS has good intra-vendor scan-rescan repeatability (CCC = 99.2% and 98.8% ) and cross-vendor reproducibility (CCC=96.3%). With continued effort, we hope to show that qDESS T2 relaxometry can serve as a reliable clinical biomarker for early OA diagnosis.