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Abstract #4915

Assessment of two T1D components within myelinated tissue with ihMT MRI

Victor N. D. Carvalho1,2, Olivier M. Girard1, Andreea Hertanu1, Samira Mchinda1, Lucas Soustelle1, Axelle Grélard3, Antoine Loquet3, Erick J. Dufourc3, Gopal Varma4, David C. Alsop4, Pierre Thureau2, and Guillaume Duhamel1

1Aix Marseille Univ, CNRS, CRMBM UMR 7339, Marseille, France, 2Aix Marseille Univ, CNRS, ICR UMR 7273, Marseille, France, 3CBMN UMR 5248, CNRS University of Bordeaux, Pessac, France, 4Department of Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

T1D, the relaxation time of the dipolar order, is a probe for membrane dynamics and organization that could be used to assess myelin integrity. A single-component T1D model associated with a modified ihMT sequence had been proposed for in vivo evaluation of T1D with MRI. However, experiments and simulations revealed that myelinated tissues exhibit multiple T1D components. A bi-component T1D model is proposed and validated. Fits in a rat spinal cord yield two T1Ds of about 10 ms and 400 μs. The results suggest that myelin has a dynamically heterogeneous organization.

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