Relative static tissue signal differences between neighboring slices across slice bands in MB-EPI PCASL imaging with background suppression (BS) are dramatically larger than those in MB-EPI PCASL imaging without BS, and can result in severe subtraction errors/artifacts for imaging data with large subject motion that sometimes cannot be corrected or removed by motion correction. To resolve this issue, alternative slice acquisition orders are proposed and evaluated. Our results suggest that the proposed alternative slice acquisition orders can improve the robustness of MB-EPI PCASL imaging with BS, providing comparable CBF estimates with minimized subtraction errors.
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