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Abstract #4971

Observation and Mitigation of Magnetization Transfer Effects in the two-point 3D Variable Flip Angle T1 Mapping Technique at 3T

Jean-David Jutras1, Atefeh Kordzadeh2, and Nicola De Zanche3,4

1Medical Physics, Cancer Centre of Southeastern Ontario, Kingston, ON, Canada, 2Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 3Oncology, University of Alberta, Edmonton, AB, Canada, 4Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada

The Variable Flip Angle (VFA) T1 mapping technique has been employed extensively in the past given its high contrast-to-noise ratio per unit scan time. However, its sensitivity to B1 field inhomogeneity and imperfect spoiling hinders its reproducibility among different scanners and imaging centers. In this study, we investigate the impact of magnetization transfer (MT) effects in a 3D VFA technique using fixed flip angles, while varying B1 amplitudes and durations, following corrections for non-ideal RF spoiling and RF inhomogeneity. We show that via careful tuning of the RF pulse amplitudes and durations, MT effects can be mitigated, yielding T1 measurements that match closely with a gold-standard IR-EPI technique.

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