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Abstract #4972

The influence of fat on T1 mapping of the liver: a comparison of Look-Locker and variable-flip-angle techniques

Claudia Fellner1, Niklas Verloh1, Dominik Nickel2, Stephan Kannengießer2, Christian Stroszczynski1, and Michael Haimerl1

1Institute of Radiology, University Hospital Regensburg, Regensburg, Germany, 2MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

In 383 patients two methods for T1 mapping – 2D Look-Locker (LL), and 3D variable-flip-angle (VFA) combined with a 2-point-Dixon technique – were compared and their correlation with the intrahepatic proton density fat fraction (PDFF) was evaluated. T1_LL showed a moderate positive correlation with PDFF, while there was an intermediate negative correlation between T1_VFA_in (T1 calculated from water and fat in-phase signal) and PDFF; T1_VFA_W (T1 calculated from water only signal) was nearly independent of PDFF. In patients with PDFF above 5%, LL, VFA_in, and VFA_W yielded significantly different results for T1.

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