Abstract #4972

The influence of fat on T1 mapping of the liver: a comparison of Look-Locker and variable-flip-angle techniques

Claudia Fellner¹, Niklas Verloh¹, Dominik Nickel², Stephan Kannengießer², Christian Stroszczynski¹, and Michael Haimerl¹

¹Institute of Radiology, University Hospital Regensburg, Regensburg, Germany, ²MR Applications Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

In 383 patients two methods for T1 mapping – 2D Look-Locker (LL), and 3D variable-flip-angle (VFA) combined with a 2-point-Dixon technique – were compared and their correlation with the intrahepatic proton density fat fraction (PDFF) was evaluated. T1_LL showed a moderate positive correlation with PDFF, while there was an intermediate negative correlation between T1_VFA_in (T1 calculated from water and fat in-phase signal) and PDFF; T1_VFA_W (T1 calculated from water only signal) was nearly independent of PDFF. In patients with PDFF above 5%, LL, VFA_in, and VFA_W yielded significantly different results for T1.

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