Abstract #4974

Investigating the T1 of human venous blood at 7T in patients with diabetes, metabolic syndrome and healthy subjects.

Dimo Ivanov¹, Roy AM Haast^1,2, Muriel Desmond-Kennedy¹, Benedikt A Poser¹, and Kâmil Uludağ^1,3

¹Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ²Centre for Functional and Metabolic Mapping, University of Western Ontario, London, ON, Canada, ³Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

Blood T₁ values are important to accurately quantify perfusion with arterial spin labeling and to determine the optimal inversion time for vascular space occupancy and black-blood imaging. In this work, we demonstrate that a post-hoc B₁⁺-corrected MP2RAGE sequence can be used to measure the subject-specific T₁ of blood in the superior sagittal sinus at 7T, eliminating the need for additional dedicated measurement. The approach was applied in patients with diabetes, metabolic syndrome and healthy controls to examine the influence of these conditions on the respective T₁ of blood. The method proposed can be employed at any field strength.

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