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Abstract #4974

Investigating the T1 of human venous blood at 7T in patients with diabetes, metabolic syndrome and healthy subjects.

Dimo Ivanov1, Roy AM Haast1,2, Muriel Desmond-Kennedy1, Benedikt A Poser1, and Kâmil Uludağ1,3

1Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2Centre for Functional and Metabolic Mapping, University of Western Ontario, London, ON, Canada, 3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

Blood T1 values are important to accurately quantify perfusion with arterial spin labeling and to determine the optimal inversion time for vascular space occupancy and black-blood imaging. In this work, we demonstrate that a post-hoc B1+-corrected MP2RAGE sequence can be used to measure the subject-specific T1 of blood in the superior sagittal sinus at 7T, eliminating the need for additional dedicated measurement. The approach was applied in patients with diabetes, metabolic syndrome and healthy controls to examine the influence of these conditions on the respective T1 of blood. The method proposed can be employed at any field strength.

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