Abstract #4977

Inversion-recovery MRI based biphasic analysis of porous media: simulations, phantom experiments and in vivo brain study.

Ledia Lilaj¹, Jürgen Braun ², Thom Fischer³, Ingolf Sack¹, and Sebastian Hirsch^4,5

¹Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Institut of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Department of Radiology, Interdisciplinary Ultrasound Center, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁵Bernstein Center for Computational Neuroscience, Charité – Universitätsmedizin Berlin, Berlin, Germany

A novel technique that combines inversion recovery MRI (IR-MRI) and a biphasic porous tissue model is introduced to quantify in every voxel the porosity, defined as the ratio between the volume of the fluid phase and the total volume of both the fluid and the solid matrix. Simulations revealed precise results over a wide range of values.

Porosities of tofu phantoms measured by IR-MRI were in good agreement with the values obtained from reference methods, confirming the stability of our technique.

The same IR-MRI method was then applied to the brains of healthy volunteers providing quantitative maps of porosity.

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