Abstract #0097

Neurometabolism in children with chronic liver disease or portosystemic shunting: a 1H-MRS/MRI study at 7T

Cristina Cudalbu¹, Lijing Xin¹, Bénédicte Maréchal^2,3,4, Tobias Kober^2,3,4, Sarah Lachat⁵, Nathalie Valenza⁶, Florence Zangas-Gehri⁶, and Valérie McLin⁵

¹Centre d'Imagerie Biomedicale, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, ²Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ³Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁴LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁵Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, and University of Geneva Medical School, Geneva, Switzerland, ⁶Pediatric Neurology Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, and University of Geneva Medical School, Geneva, Switzerland

Children with chronic liver disease (CLD) or congenital portosystemic shunts (CPSS) show neurocognitive deficits that are not entirely reversible following liver transplantation or shunt closure. We measured for the first time the neurometabolic profile, brain volumetry and T1 relaxation times of children with CLD and CPSS at 7T. In patients with compensated CLD, there were no significant neurometabolic alterations as assessed by 1H-MRS, while small changes in amygdala and hippocampus volumes were measured. In CPSS, however, neurometabolic changes were pronounced, together with a marked decrease in all measured brain volumes, and likely related to measurably impaired neurocognitive functioning.

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