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Abstract #0161

Real-time MR elastography of the human brain reveals short-term cerebral autoregulation in response to the Valsalva maneuver.

Helge Herthum1, Mehrgan Shahryari1, Gergely Bertalan1, Carsten Warmuth1, Stefan Hetzer2, Jürgen Braun3, and Ingolf Sack1
1Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Bernstein Center for Computational Neuroscience, Berlin, Germany, 3Institute of Medical Informatics, Berlin, Germany

Real-time MR elastography (rt-MRE) with 4.9Hz-frame rate was developed for in-vivo brain stiffness quantification during short-term tissue mechanical adaptation due to cerebral autoregulation. Six healthy participants performed a 15s-Valsalva maneuver with 50s recovery period following 10s resting period and 5s deep inspiration during continuous rt-MRE. 387 maps of tissue stiffness and fluidity were generated depicting a significant increase of stiffness due to Valsalva and an overshoot of stiffness by 3.4% fading out within 7s after the maneuver. rt-MRE is potentially sensitive to several diseases associated with cerebral autoregulation and reveals new insights into brain viscoelasticity changes on short time scales.

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