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Abstract #0239

Disconnectome-Symptom Mapping in Traumatic Brain Injury: Application to Paediatric Populations

Adam J Shephard1, Jan Novak1, Cathy Catroppa2, Vicki Anderson2, and Amanda G Wood1,3
1School of Life & Health Sciences & Aston Neuroscience Institute, Aston University, Birmingham, United Kingdom, 2Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Australia, 3School of Psychology, Deakin University, Geelong, Australia

Disconnectome-symptom mapping (DSM) was used to identify relationships between brain and behaviour, by assessing the effect of pathology-intersected white matter tracts on neuropsychological outcomes. This study used DSM to see how IQ, two years post-injury, related to disconnections in the brain, following paediatric traumatic brain injury. For this, two approaches were employed: the BCBtoolkit, designed for use in adults, and a child-analogue. This study found the BCBtoolkit to be less sensitive than the child-analogue, however, in both methods, disconnections in the superior longitudinal fasciculus and external capsule correlated with a reduced IQ when comparing disconnected patients to controls.

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