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Abstract #0256

Lymphatic insufficiency observed by noninvasive MR lymphangiography and multi-nuclear 23Na-MRI in patients with lymphedema and lipedema

Rachelle Crescenzi1, Paula M.C. Donahue2,3, Kalen J Petersen1, Maria Garza1, Kelsey Guerreso1, Yu Luo1, Joshua A. Beckman4, and Manus J. Donahue1,5,6
1Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Dayani Center for Health and Wellness, Vanderbilt University Medical Center, Nashville, TN, United States, 3Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 4Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, 5Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 6Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States

The lymphatic system comprises a central component of the circulatory system, yet imaging approaches to visualize lymphatics remain underdeveloped. We utilized MR lymphangiography and sodium MRI to confirm lymphatic impairment in patients with lymphedema of known causes, and in patients with the adipose disorder lipedema of unknown etiology. We report distinct profiles on MR lymphangiography that correlate with tissue sodium and fat deposition. Results provide evidence of lymphatic involvement in lipedema that informs disease mechanisms related to swelling, and more broadly relates to lymphatic clearance dysfunction in a range of diseases where sodium and fat are implicated.

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