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Abstract #0257

Quantitative Assessment of Articular Cartilage Degeneration Using 3D Ultrashort Echo Time Cones Adiabatic T1ρ (3D UTE Cones AdiabT1ρ) Imaging

Mei Wu1,2, Yanping Xue1, Yajun Ma1, Claire Tang1, Meghan Shen1, Saeed Jerban1, Eric Y Chang1,3, and Jiang Du1
1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

The study protocol included three-dimensional Ultrashort Echo Time Cones actual flip angle imaging (3D UTE-Cones-AFI) for T1 measurement and UTE-Cones with adiabatic T1ρ (AdiabT1ρ) preparation for AdiabT1ρ measurement. We applied the 3D UTE-Cones AdiabT1ρ sequence to healthy volunteers and patients with different degrees of OA for a systematic evaluation of its clinical performance. Results showed that the 3D UTE-Cones AdiabT1ρ sequence could be used for high resolution imaging and quantitative assessment of the knee cartilage, and that the AdiabT1ρ biomarker showed a significant positive relationship with WORMS.

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