Abstract #0257

Quantitative Assessment of Articular Cartilage Degeneration Using 3D Ultrashort Echo Time Cones Adiabatic T1ρ (3D UTE Cones AdiabT1ρ) Imaging

Mei Wu^1,2, Yanping Xue¹, Yajun Ma¹, Claire Tang¹, Meghan Shen¹, Saeed Jerban¹, Eric Y Chang^1,3, and Jiang Du¹

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Department of Radiology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, ³Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

The study protocol included three-dimensional Ultrashort Echo Time Cones actual flip angle imaging (3D UTE-Cones-AFI) for T1 measurement and UTE-Cones with adiabatic T1ρ (AdiabT1ρ) preparation for AdiabT1ρ measurement. We applied the 3D UTE-Cones AdiabT1ρ sequence to healthy volunteers and patients with different degrees of OA for a systematic evaluation of its clinical performance. Results showed that the 3D UTE-Cones AdiabT1ρ sequence could be used for high resolution imaging and quantitative assessment of the knee cartilage, and that the AdiabT1ρ biomarker showed a significant positive relationship with WORMS.

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