Abstract #0258

Principal Component Analysis of Simultaneous PET/MRI Reveals Patterns of Cartilage-Bone Interactions in Osteoarthritis

Radhika Tibrewala¹, Valentina Pedoia¹, Matthew Bucknor¹, and Sharmila Majumdar¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Osteoarthritis (OA) is a joint disorder, consisting of cartilage degeneration and metabolic bone changes, which have previously been correlated by using [¹⁸F]-NaF PET/MRI in the knee. However, these correlations were derived using averaging methods in areas of [¹⁸F] uptake in the bone and surrounding cartilage T_1ρ/T₂ mean values, which could miss potential multifaceted mechanisms that are not spatially correlated in the joint. The goal of this study is to find complex patterns in OA by building a cartilage-bone interface and using principal component analysis to find cartilage-bone interactions and find associations with known manifestations of OA.

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