Abnormal bone physiology is a potential mechanism for the progression of knee osteoarthritis. Molecular information derived from PET imaging has shown promise in early detection of bone metabolic abnormalities. Here we investigated kinetic parameters of PET tracer ([18F]-NaF) uptake in subjects with knee osteoarthritis and evaluated the relationship between kinetic tracer uptake parameters and structural MRI findings. The kinetic parameters for [18F]-NaF delivery and uptake to regions of bone containing osteophytes, bone marrow lesions, and adjacent to cartilage lesions identified on MRI were significantly different compared to normal-appearing bone, suggesting strong spatial relationships between structural damage and bone metabolic abnormalities.
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