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Abstract #0260

Quantitative Measurements of Bone Water and 31P in Postmenopausal Women: A Preliminary Study

Brandon Clinton Jones1, Cheng-Chieh Cheng1, Xia Zhao1, Mona Al Mukaddam2, Peter J Snyder2, Chamith S Rajapakse1, Hee Kwon Song1, and Felix W Wehrli1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Medicine, University of Pennsylvania, Philadelphia, PA, United States

Seven osteoporotic treatment-naïve and 13 non-osteoporotic postmenopausal women have been examined in an ongoing MRI study to evaluate cortical bone properties. 1H dual-echo UTE and 1H IR-prepared rapid-UTE sequences were used for evaluation of pore and bound water concentrations in the tibial cortex, and a 31P PETRA-ZTE sequence for quantification of cortical bone mineralization. Elevated total water and pore water were found in the osteoporotic group (p=0.036, p=0.032), whereas 31P and bound water concentrations were not significantly different. Since pore water is a known surrogate of bone porosity, our preliminary results suggest it may be useful in evaluating bone health.

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