Abstract #0261

Can Tumor T1 Serve as Early Response Imaging Biomarker for Neoadjuvant Chemotherapy in Osteosarcoma? A Preliminary Study

Esha Baidya Kayal¹, Nikhil Sharma¹, Sameer Bakhshi², Raju Sharma³, Devasenathipathy Kandasamy³, and Amit Mehndiratta^1,4

¹Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India, ²Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences, New Delhi, New Delhi, India, ³Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁴Department of Biomedical engineering, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Histopathological examination is the current gold standard for evaluating tumor response to anti-cancer therapy; though it is possible only after surgery. Non-invasive imaging biomarkers of tumor response to therapy may be useful in optimizing existing treatments improving overall outcome. The spin-lattice relaxation time of water protons (T1) reflects therapeutic changes in tumor and is thus a generic marker of tumor response to therapy. Experimental results showed T1 relaxation time reduces upon successful chemotherapy and thus, a change in tumor T1 may be a non-invasive imaging marker of chemo-sensitivity and chemotherapy response.

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