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Abstract #0383

Penumbra Identification in Acute Stroke Using Fast 3D 1H-MRSI

Yao Li1, Zengping Lin1, Tianyao Wang2, Tianxiao Zhang1, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Ziyu Meng1,3, Jun Liu2, Xin Yu5, and Zhi-Pei Liang3,4
1Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Impaired metabolism was a key factor in the definition of ischemic penumbra. 1H-MRSI has been recognized as a potentially powerful tool for metabolic imaging of stroke. In this proof of concept clinical study, we explored the potential of fast 3D high-resolution 1H-MRSI to investigate brain neurometabolic changes at tissue-level in acute stroke. In a 6-min scan, we obtained N-acetylaspartate (NAA) and lactate (Lac) maps simultaneously. Our experimental results showed different NAA and Lac concentrations between hypoperfused tissue recruited to final infarct and that survived, indicating an improved delineation of penumbra by incorporating the tissue neuronal damage and acidosis information.

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