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Abstract #0384

Detection of Carbonic Anhydrase Activity in the Frontal Lobe of Human Brain

Shizhe Li1, Li An1, Christopher Johnson1, Maria Ferraris-Araneta1, Milalynn Victorino1, Jyoti Tomar1, and Jun Shen1
1National Institutes of Health, Bethesda, MD, United States

This study demonstrates the feasibility of detecting carbonic anhydrase activity in the frontal lobe of the human brain. Upon saturation of carbon dioxide, a very large magnetization transfer effect catalyzed by carbonic anhydrase was measured in the frontal lobe of healthy human subjects using 13C MRS with oral administration of [U-13C6]glucose. The results showed that it is feasible to examine carbonic anhydrase activity using magnetization transfer 13C MRS in the frontal cortex—where structural lesions, disturbed function, and morphology are strongly associated with many psychiatric symptoms.

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