Abstract #0406

The Effect of Tumor Grade within IDH Wild-Type and IDH Mutant Gliomas Assessed by Proton Magnetic Resonance Spectroscopy at 3T

Esin Ozturk-Isik^1,2, Banu Sacli Bilmez¹, Ayca Ersen Danyeli^2,3, Cengiz Yakicier⁴, Alpay Ozcan^2,5,6, M. Necmettin Pamir^2,5,7, Koray Ozduman^2,5,7, and Alp Dincer^2,5,8

¹Institute of Biomedical Engineering, Bogaziçi University, Istanbul, Turkey, ²Brain Tumor Research Group, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ³Department of Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁴Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁵Center for Neuroradiological Applications and Research, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁶Department of Medical Device Technologies, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁷Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, ⁸Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Isocitrate dehydrogenase (IDH) mutation highly affects the overall survival of gliomas. In addition to the IDH mutation, the tumor histologic grade might play a role in patient prognosis. The aim of this study was to assess the metabolic variations between different tumor grades within IDH mutant (IDH-mut) and IDH wild-type (IDH-wt) gliomas using proton MR spectroscopy. Higher glycine in glioblastoma (GBM) within IDH-mut, and lower Cr and mIns in GBM within IDH-wt were the only statistically significant differences. Our study indicated similar metabolic profiles of different grades within IDH mutational subgroups, supporting IDH as a better predictor of clinical outcome.

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