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Abstract #0406

The Effect of Tumor Grade within IDH Wild-Type and IDH Mutant Gliomas Assessed by Proton Magnetic Resonance Spectroscopy at 3T

Esin Ozturk-Isik1,2, Banu Sacli Bilmez1, Ayca Ersen Danyeli2,3, Cengiz Yakicier4, Alpay Ozcan2,5,6, M. Necmettin Pamir2,5,7, Koray Ozduman2,5,7, and Alp Dincer2,5,8
1Institute of Biomedical Engineering, Bogaziçi University, Istanbul, Turkey, 2Brain Tumor Research Group, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 3Department of Pathology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 4Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 5Center for Neuroradiological Applications and Research, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 6Department of Medical Device Technologies, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 7Department of Neurosurgery, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, 8Department of Radiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey

Isocitrate dehydrogenase (IDH) mutation highly affects the overall survival of gliomas. In addition to the IDH mutation, the tumor histologic grade might play a role in patient prognosis. The aim of this study was to assess the metabolic variations between different tumor grades within IDH mutant (IDH-mut) and IDH wild-type (IDH-wt) gliomas using proton MR spectroscopy. Higher glycine in glioblastoma (GBM) within IDH-mut, and lower Cr and mIns in GBM within IDH-wt were the only statistically significant differences. Our study indicated similar metabolic profiles of different grades within IDH mutational subgroups, supporting IDH as a better predictor of clinical outcome.

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