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Abstract #0446

Voxel-wise comparison of co-registered quantitative CT and hyperpolarized gas diffusion-weighted MRI measurements in IPF

Ho-Fung Chan1, Alberto Biancardi1, Bilal A Tahir1, Nicholas D Weatherley1, Ronald A Karwoski2, Brian J Bartholmai2, Stephen M Bianchi3, and Jim M Wild1
1Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, United States, 3Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

A framework for spatial co-registration of 3He diffusion-weighted (DW)-MRI and high resolution CT (HRCT) images was developed and implemented in a cohort of fifteen idiopathic pulmonary fibrosis participants. Voxel-wise comparison of 3He DW-MRI derived apparent diffusion coefficient (ADC) and mean alveolar dimension (LmD­) with CALIPER image analysis software classifications revealed that the largest DW-MRI metrics are in voxels classified as honeycombing. Furthermore, LmD values in voxels classified as normal by CALIPER were larger than those from age-matched healthy volunteers, suggesting DW-MRI may detect microstructural changes even in areas of the lung determined as macroscopically normal by HRCT.

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