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Abstract #0447

Hyperpolarized 129Xe Imaging of Oxygenated and Deoxygenated Blood in a Free-Breathing Mouse

Luis A Loza1, Stephen J Kadlecek1, Mehrdad Pourfathi1, Kai Ruppert1, Tahmina S Achekzai1, Ian F Duncan1, and Rahim R Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States

129Xe’s high solubility in tissue and blood, coupled with its dramatic change in chemical shift based on local chemical environment, enables quantitative measurements of blood oxygenation. In this work, we demonstrate a technique for distinguishing oxygenated vs. deoxygenated blood in the mouse circulatory system in vivo. Time-resolved dissolved-phase images and spectra were used to identify spectral signatures for 129Xe dissolved in oxygenated and deoxygenated blood, which were then applied to a mouse model of lung cancer to temporally assess regional changes in pulmonary blood oxygenation. The results presented here demonstrate

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