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Abstract #0448

Dual Center and Dual Vendor feasibility of perfusion-weighted phase resolved functional lung (PREFUL) MRI in CF patients

Lea Behrendt1,2, Andreas Voskrebenzev1,2, Cristian Crisosto Gonzalez1,2, Marcel Gutberlet1,2, Helen Marshall3, Anna-Maria Dittrich4, Laurie Smith3, Paul Hughes3, Jim Wild3, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3University of Sheffield, Sheffield, United Kingdom, 4Paediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany

Dynamic contrast enhanced (DCE) MRI is an established technique for measurement of lung perfusion, but requires the administration of contrast agents and a breath hold. Thus, methods for contrast agent free assessment of lung perfusion in free breathing, like phase resolved functional lung (PREFUL) MRI, are desirable. Therefore, in this dual center and dual vendor feasibility study, we validated PREFUL MRI against DCE MRI in patients with CF. Perfusion defect percentage (QDP) maps of both methods were calculated, showing an overlap of 61% for the whole lung. Further, a strong correlation between QDPPREFUL and QDPDCE was found (r=0.70, p=0.005).

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