Abstract #0448

Dual Center and Dual Vendor feasibility of perfusion-weighted phase resolved functional lung (PREFUL) MRI in CF patients

Lea Behrendt^1,2, Andreas Voskrebenzev^1,2, Cristian Crisosto Gonzalez^1,2, Marcel Gutberlet^1,2, Helen Marshall³, Anna-Maria Dittrich⁴, Laurie Smith³, Paul Hughes³, Jim Wild³, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³University of Sheffield, Sheffield, United Kingdom, ⁴Paediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany

Dynamic contrast enhanced (DCE) MRI is an established technique for measurement of lung perfusion, but requires the administration of contrast agents and a breath hold. Thus, methods for contrast agent free assessment of lung perfusion in free breathing, like phase resolved functional lung (PREFUL) MRI, are desirable. Therefore, in this dual center and dual vendor feasibility study, we validated PREFUL MRI against DCE MRI in patients with CF. Perfusion defect percentage (QDP) maps of both methods were calculated, showing an overlap of 61% for the whole lung. Further, a strong correlation between QDP_PREFUL and QDP_DCE was found (r=0.70, p=0.005).

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