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Abstract #0576

Probing ballistic flow in the placenta using flow-compensated and non-compensated diffusion MRI

Ling Jiang1,2, Taotao Sun1,2, Yuhao Liao3, Yi Sun4, Yi Zhang3, Zhaoxia Qian1,2, and Dan Wu3
1Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China, 3Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 4MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Intravoxel incoherent motion (IVIM) imaging is frequently used to evaluate microcirculatory flow. With the conventional diffusion MRI, IVIM effects include both pseudo-diffusive microcirculatory flow and bulk (or ballistic) blood flow. We propose a joint use of flow-compensated (FC) and non-FC diffusion gradient waveforms to specifically probe the fraction and velocity of ballistic flow in the placenta. The measured ballistic flow velocity showed a high correlation with umbilical flow based on Doppler ultrasound and a negative correlation with gestational age. These results demonstrated the potential of using FC/NC dMRI to noninvasively measure flow velocity inside the placenta.

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