Abstract #0631

Cerebral metabolism of hyperpolarized [2H7, U-13C6]D-glucose in the healthy mouse under different anesthetic conditions

Emmanuelle Flatt¹, Bernard Lanz¹, Andrea Capozzi¹, Magnus Karlsson², Mathilde H.Lerche², Rolf Grütter^1,3, and Mor Mishkovsky¹

¹LIFMET, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Danmarks Tekniske Universitet, Lyngby, Denmark, ³CIBM, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Glucose is the primary fuel for the brain and its metabolism is linked with cerebral function. Isoflurane anesthesia is commonly employed in preclinical MRS but influences functional connectivity. The combination of isoflurane and medetomidine is regularly used in rodent fMRI and show similar functional connectivity as in awake animals. Here we compared the cerebral metabolism of hyperpolarized [²H₇,U-¹³C₆]-D-glucose under these two anesthetic conditions. When using the combination, the [1-¹³C]lactate signal and lactate-to-glucose ratio were more than doubled compared to isoflurane solely, showing that the change of anesthesia had a high impact on cerebral glucose uptake and glycolytic flux.

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