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Abstract #0632

Hyperpolarized 13C Pyruvate Imaging of Glioblastoma Patients

Jun Chen1, Toral Patel2, Crystal E Harrison1, Galen D Reed3, Craig R Malloy1, Bruce Mickey2, and Jae Mo Park1,4,5
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3GE Healthcare, GE Healthcare, Dallas, TX, United States, 4Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Electrical Engineering, University of Texas Dallas, Richardson, TX, United States

Noninvasive tumor characterization is extremely beneficial for brain tumor patients for establishing surgical procedure and treatment plans. In this study, we imaged newly diagnosed glioblastoma patients using hyperpolarized [1-13C]pyruvate few days prior to surgical procedures and compared the imaging and biopsy results to evaluate the diagnostic values of hyperpolarized pyruvate imaging. Brain regions with increased 13C-lactate production are confirmed as glioblastoma from stereotactic tissue-biopsy. This pilot study with treatment-naïve or newly diagnosed brain tumor patients suggest that preoperative metabolic imaging with hyperpolarized [1-13C]pyruvate may have strong diagnostic value with potential to be an alternative method for tissue biopsy.

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