Noninvasive tumor characterization is extremely beneficial for brain tumor patients for establishing surgical procedure and treatment plans. In this study, we imaged newly diagnosed glioblastoma patients using hyperpolarized [1-13C]pyruvate few days prior to surgical procedures and compared the imaging and biopsy results to evaluate the diagnostic values of hyperpolarized pyruvate imaging. Brain regions with increased 13C-lactate production are confirmed as glioblastoma from stereotactic tissue-biopsy. This pilot study with treatment-naïve or newly diagnosed brain tumor patients suggest that preoperative metabolic imaging with hyperpolarized [1-13C]pyruvate may have strong diagnostic value with potential to be an alternative method for tissue biopsy.
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