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Abstract #0633

Assessing tumor cell death in vivo usingĀ 2H-labeled fumarate and deuterium magnetic resonance spectroscopic imaging

Friederike Hesse1, Vencel Somai1,2, Flaviu Bulat1, Felix Kreis1, and Kevin Brindle1,3
1Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Monitoring tumor responses to treatment using metabolic imaging can give an early indication of outcome. We show here that Deuterium Metabolic Imaging (DMI) with 2H-labelled fumarate can be used to detect early evidence of cell death following drug treatment in a pre-clinical murine lymphoma model. 2H spectra were acquired from tumors with a time resolution of 5 min, following a bolus injection of 2H-labelled fumarate. Within 48 h of etoposide treatment the rate of tumor malate production from the labelled fumarate increased significantly. Increased levels of labelled malate were also evident in spectroscopic images of the tumors.

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