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Abstract #0664

Edge-preserving B0 inhomogeneity distortion correction for high-resolution multi-echo ex vivo MRI at 7T

Divya Varadarajan1,2, Robert Frost1,2, Andre van der Kouwe1,2, Leah Morgan1, Bram Diamond1, Emma Boyd1, Morgan Fogarty1, Allison Stevens1, Bruce Fischl1,2, and Jonathan R Polimeni1,2,3
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Harvard-MIT HST, Cambridge, MA, United States

High-resolution multi-echo MRI at ultra-high field for ex vivo imaging is time consuming, SNR starved and suffers from B0 inhomogeneity induced geometric distortions due to low-bandwidth in the readout direction. Fieldmap-based correction cannot correct singularities in regions of severe distortion, and reversed gradient (RG) approaches double the scan time. We propose to combine an alternating-polarity acquisition scheme for multi-echo MRI with a low-resolution fieldmap based novel distortion correction algorithm that can correct singularities in half the scan time of RG and enhance SNR while preserving edges. We show several ex vivo corrected results and demonstrate generalizability to in vivo MRI.

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