Abstract #0699

Metabolic Imaging of a Porcine Model of Acute Lung Injury Using Hyperpolarized [1-13C] Pyruvate MRI

Mehrdad Pourfathi¹, Hooman Hamedani^1,2, Yi Xin^1,2, Michael Rosalino¹, Stephen J Kadlecek¹, Ian Duncan¹, Maurizio Cereda^1,3, Sarmad Siddiqui¹, Harrilla Profka¹, Luis Loza¹, Faraz Amzajerdian ^1,2, Tahmina Achekzai¹, Kai Ruppert¹, Federico Sertic^1,4, Ryan Baron¹, Jon Snow¹, Yiwen Qian^1,2, Gabriel Unger¹, Shampa Chatterjee⁵, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, ⁴Surgery, University of Pennsylvania, Philadelphia, PA, United States, ⁵Physiology, University of Pennsylvania, Philadelphia, PA, United States

Transpulmonary lactate gradient is strongly correlated with the severity of lung injury and inflammation in ARDS patients. Hyperpolarized [1-¹³C] pyruvate MRI allows us to quantitatively study altered pyruvate-to-lactate conversion in cancerous and inflamed tissues. We sought to demonstrate the translational potential of this technology for pulmonary metabolic imaging in humans. We performed [1-¹³C] pyruvate lung MRI in an experimental model of aspiration pneumonitis in pigs, demonstrating this technology’s capacity to detect changes in pulmonary anaerobic metabolism after inflammatory injury in larger species.

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