Meeting Banner
Abstract #0742

Measuring the full diffusional intra- and inter-compartmental kurtosis tensors using double diffusion encoding

Rafael Neto Henriques1, Jonas Lynge Olesen 2,3, Sune Nørhøj Jespersen2,3, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Clinical Institute, Aarhus University, Aarhus, Denmark, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Diffusional kurtosis imaging (DKI) quantifies the non-Gaussian degree of diffusion using the kurtosis tensor. However, kurtosis can depend on conflicting sources of non-Gaussian diffusion such as Gaussian diffusion variance (inter-compartmental kurtosis) or the presence of restricted and hindered effects inside compartments (intra-compartmental kurtosis). Here, we develop and apply a novel double diffusion encoding method that is capable of providing the full directional dependence of both inter- and intra-compartmental kurtosis which can be summarized into two distinct kurtosis tensors and thereby improving kurtosis specificity and potentially providing information for diffusion model validation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here