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Abstract #0743

Perivascular space fluid contribute to diffusion signal attenuation at low b-value, revisiting extra-cellular space diffusion

Farshid Sepehrband1
1Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, United States

Perivascular space (PVS) is a pial-lined, fluid-filled structure that surrounds vessels in the cerebral cortex 1,2, and occupies a large portion of the cerebral tissue. The contribution of PVS fluid diffusion signal is less known and could be challenging distinguish from perfusion-related signal changes (or IVIM); because both are expected to affect diffusion at low b-values. Here we showed that PVS fluid significantly contributes to diffusion signal at low b-values dominating tissue or perfusion-related signal changes.

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