Abstract #0845

Random walk simulations of diffusion in human brain white matter from 3d EM validate diffusion time-dependence transverse and parallel to axons

Hong-Hsi Lee¹, Qiyuan Tian², Chanon Ngamsombat², Daniel R Berger³, Jeff W Lichtman³, Susie Y Huang², Dmitry S Novikov¹, and Els Fieremans¹

¹Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, United States

We perform for the first time Monte Carlo simulations inside realistic human intra-axonal space segmented from electron microscopy. We observe non-Gaussian time-dependent diffusion in both radial and axial directions, and validate analytical models of these phenomena. We also compare the results in human axons with similar simulations in mouse axons, and discuss how the differences in axonal parameters (mean radius, radius variation, undulations) explain the differences in the simulation results between the human and mouse.

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