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Abstract #0917

Subcortical abnormality reveal disease specific changes in amyotrophic lateral sclerosis

Sicong Tu1,2, Matthew Kiernan1, and Martin Turner2
1Brain and Mind Centre, The University of Sydney, Sydney, Australia, 2Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom

Amyorophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition affecting the motor system, but increasingly recognised as a multi-system disease. We present two studies that highlight disease specific patterns of abnormality in the thalamus and corpus callosum that suggest regional variation in neural relay structures may be promising markers of disease progression in ALS.

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