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Abstract #0920

Quantitative 31P MRS Assessment of Neurometabolic Derangement in Pediatric Concussion

Xiao-Hong Zhu1, Byeong-Yeul Lee1, Katherine Ingram2, Wei Chen1, Robert Doss2,3, and Joseph Petronio2
1CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Children’s Minnesota Neuroscience Institute, St. Paul, MN, United States, 3Department of Neurology, University of Minnesota,, Minneapolis, MN, United States

Abnormal changes in brain metabolism and its role in pediatric concussion have not been well studied. We employed 31P MRS technique at 7T to assess the neurometabolic alteration in children with concussion. Phosphorous metabolites concentrations and other key physiological parameters were measured in patient and control cohorts. Metabolic differences between healthy and concussed brains were detected at two time points after the injury. We also found that mild head trauma reduced the age-dependences of high-energy phosphates and NAD contents in the developing brain, and it took much longer than clinically defined “recovery time” to fully restore such relationship.

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