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Abstract #0975

Analysis of hub-regions from the structural connectomes of preterm-born and control adolescents

Hassna Irzan1,2, Michael Hütel2, Sebastien Ourselin2, Neil Marlow3, and Andrew Melbourne1,2
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 3Institute for Women's Health, London, United Kingdom

Preterm birth has been linked to white matter abnormalities in infants, however the functional implications of these abnormalities are poorly understood. Thus, the long-term effect of such alterations needs further investigation. By combining graph theory and statistical analysis methods, we identify and investigate the hub structure of the preterm brain. The results suggest that while the hub structure is preserved, the connectivity strength and capacity of information flow is reduced and that is linked to reduced brain volume as well as preterm birth.

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