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Abstract #0976

Structural Analysis of Whole Mouse Brain by Magnetic Resonance Histology

Nian Wang1, Leonard E. White2, Gary Cofer1, Yi Qi1, and G. Allan Johnson1
1Department of Radiology, Duke University, Durham, NC, United States, 2Department of Neurology, Duke University, Durham, NC, United States

Diffusion MRI (dMRI) encompasses a broad range of scales, physical mechanisms and models and applications from clinical to the basic sciences. The recent development of compressed sensing allowed us to extend the spatial and contrast resolution to define more subtle brain architecture beyond the meso scale, solidly in the microscopic domain. We report here dMRI at spatial resolution down to 25 μm i.e. voxels that are more 500,000 times smaller than that of the routine clinical scans.

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