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Abstract #1084

B1 Inhomogeneity at 3T causes spatially non-reproducible and inaccurate cardiac creatine CEST-contrast in healthy controls

Wissam AlGhuraibawi1, Kevin Godines1, Mark Velasquez1, Sinyeob Ahn2, Wolfgang Rehwald3, and Moriel Vandsburger1
1Bioengineering, University of California Berkeley, Berkeley, CA, United States, 2Siemens Healthineers, Concord, CA, United States, 3Siemens Healthineers, Durham, NC, United States

CEST-MRI is an emerging molecular imaging method for non-invasive assessment of cardiomyocyte metabolites. In cardiac CEST-MRI, spatial B1 inhomogeneity across the myocardium significantly reduces the accuracy of measured CEST contrasts. Deviation from the prescribed B1 leads to altered creatine CEST contrast due to both reduced labeling efficiency and heightened magnetization transfer and direct water direct saturation across the heart. The final impact is measurement of falsely and substantially reduced creatine CEST contrast in the healthy heart.

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