Accurate risk stratification and predicting tumor aggressiveness is critically important for the management of papillary thyroid cancer. The results from the present study predict tumor aggressiveness in papillary thyroid cancer using noninvasive multi-parametric MRI (i.e. non-Gaussian intravoxel incoherent motion (NG-IVIM) diffusion weighted (DW) and dynamic contrast-enhanced (DCE)-MRI). The surrogate biomarkers of tumor vascularity (Ktrans) and tumor cellularity (D) were negatively correlated. The kurtosis coefficient (K) reflecting tissue microstructure showed a moderate and significant correlation with the contrast agent leakage space (ve). DWI and DCE-MRI derived metrics can predict tumor aggressiveness in PTC.