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Abstract #1194

Human 13C Hybrid-Shot Spiral (HYSS) Imaging of Pathological Cardiac Metabolism Following Myocardial Infarction

Justin YC Lau1,2, Andrew Apps1, Jack JJJ Miller1,2,3, Andrew Tyler2, Liam AJ Young1, Andrew JM Lewis1, Gareth Barnes4, Claire Trumper1, Stefan Neubauer1, Oliver J Rider1, and Damian J Tyler1,2
1Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 3Department of Physics, University of Oxford, Oxford, United Kingdom, 4Royal Brompton & Harefield NHS Foundation Trust, Harefield, United Kingdom

This study reports the clinical translation of a hybrid-shot spiral sequence (HYSS) for imaging the diseased heart and spleen. Two subjects with myocardial infarction from coronary artery disease were imaged following administration of hyperpolarized [1-13C]pyruvate. High lactate and bicarbonate signal were seen in the region adjacent to the infarcted zone, with no signal within the infarct. A large splenic lactate signal was observed in a subject with an active systemic inflammatory response post myocardial infarction.

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