Abstract #1194

Human 13C Hybrid-Shot Spiral (HYSS) Imaging of Pathological Cardiac Metabolism Following Myocardial Infarction

Justin YC Lau^1,2, Andrew Apps¹, Jack JJJ Miller^1,2,3, Andrew Tyler², Liam AJ Young¹, Andrew JM Lewis¹, Gareth Barnes⁴, Claire Trumper¹, Stefan Neubauer¹, Oliver J Rider¹, and Damian J Tyler^1,2

¹Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ³Department of Physics, University of Oxford, Oxford, United Kingdom, ⁴Royal Brompton & Harefield NHS Foundation Trust, Harefield, United Kingdom

This study reports the clinical translation of a hybrid-shot spiral sequence (HYSS) for imaging the diseased heart and spleen. Two subjects with myocardial infarction from coronary artery disease were imaged following administration of hyperpolarized [1-¹³C]pyruvate. High lactate and bicarbonate signal were seen in the region adjacent to the infarcted zone, with no signal within the infarct. A large splenic lactate signal was observed in a subject with an active systemic inflammatory response post myocardial infarction.

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