Abstract #1227

Sub-Millimeter Spiral fMRI Combining Magnitude and Phase BOLD Contrast

Lars Kasper¹, Maria Engel¹, Jakob Heinzle², Matthias Mueller-Schrader², Jonas Reber¹, Thomas Schmid¹, Christoph Barmet¹, Bertram Jakob Wilm¹, Klaas Enno Stephan^2,3,4, and Klaas Paul Pruessmann¹

¹Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland, ²Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, ³Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, ⁴Max Planck Institute for Metabolism Research, Cologne, Germany

We investigate the spatial specificity of sub-millimeter (0.8mm) single-shot spiral fMRI, and its feasibility for functional phase contrast. Scrutinizing activation patterns of a visual paradigm in 6 subjects, we find that significant contrast changes occur between adjacent voxels, contributing to the evidence of spatial specificity of spiral acquisition as well as gradient echo BOLD contrast, and its possible applications in laminar or columnar fMRI. Furthermore, the vessel-localized nature of the phase activation suggests its suitability for masking macrovascular confound effects.

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