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Abstract #1227

Sub-Millimeter Spiral fMRI Combining Magnitude and Phase BOLD Contrast

Lars Kasper1, Maria Engel1, Jakob Heinzle2, Matthias Mueller-Schrader2, Jonas Reber1, Thomas Schmid1, Christoph Barmet1, Bertram Jakob Wilm1, Klaas Enno Stephan2,3,4, and Klaas Paul Pruessmann1
1Institute for Biomedical Engineering, ETH Zurich and University of Zurich, Zurich, Switzerland, 2Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, 3Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, 4Max Planck Institute for Metabolism Research, Cologne, Germany

We investigate the spatial specificity of sub-millimeter (0.8mm) single-shot spiral fMRI, and its feasibility for functional phase contrast. Scrutinizing activation patterns of a visual paradigm in 6 subjects, we find that significant contrast changes occur between adjacent voxels, contributing to the evidence of spatial specificity of spiral acquisition as well as gradient echo BOLD contrast, and its possible applications in laminar or columnar fMRI. Furthermore, the vessel-localized nature of the phase activation suggests its suitability for masking macrovascular confound effects.

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