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Abstract #1350

M-Mapping Method for Calibrated fMRI in Awake Versus Anesthetized Mice

Binshi Bo1, Mengyang Xu2, Garth Thompson2, and Zhifeng Liang1
1Institute of Neuroscinece, CAS Center for Excellence in Brain Sciences and Intelligence Technology, Key Laboratory of Primate Neurobiology, Chinese Academy of Sciences, Shanghai, China, 2iHuman Institute, ShanghaiTech University, Shanghai, China

In functional brain imaging, the BOLD signal represents a mixture of CBF, CBV and the CMRO2. “Calibrated fMRI” methods aim to measure CMRO2 through a metabolic model, but typically require administration of gases which is not possible in many clinical settings. Here, we developed a calibrated fMRI technique called “M-Mapping” which combines CBF and R2' maps together to calculate relative CMRO2 and showed awake mice has a greater value than anesthetized mice in a region specific manner. This method may have a great potential to compare brain metabolic activity across different resting activity levels for further clinical study.

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