In functional brain imaging, the BOLD signal represents a mixture of CBF, CBV and the CMRO2. “Calibrated fMRI” methods aim to measure CMRO2 through a metabolic model, but typically require administration of gases which is not possible in many clinical settings. Here, we developed a calibrated fMRI technique called “M-Mapping” which combines CBF and R2' maps together to calculate relative CMRO2 and showed awake mice has a greater value than anesthetized mice in a region specific manner. This method may have a great potential to compare brain metabolic activity across different resting activity levels for further clinical study.
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