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Abstract #1351

Functional dissection of somatosensory processing pathways in mice

Won Beom Jung1,2, Hyun Seok Moon1,2, Taeyi You1,2, Jung Mi Lee1, and Seong-Gi Kim1,2
1Cener for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon-si, Gyeonggi-do, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea, Republic of

Somatosensory system is communicated by feedforward and feedback projection each other during functional processing. Somatosensory fMRI response is attributed to these inter-regional reciprocal projections. Therefore, the separation of functional pathways in fMRI data is important to interpret fMRI data in circuit level. Here, to dissect somatosensory fMRI response, we compared CBV-weighted fMRI obtained at 15.2T under three conditions: excitation by sensory stimulation, silencing of somatosensory cortex by optogenetic stimulation, and combined excitation and silencing.

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