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Abstract #1352

Brain-wide functional mapping of the entorhinal cortex in young 3xTg mouse model for Alzheimer’s disease

Francesca Mandino1,2, Ling Yun Yeow2, Chai Lean Teoh2, Chun-Yao Lee2, Renzhe Bi2, Hasan Mohammad2, Sejin Lee2, Han Gyu Bae2, Seung Hyun Baek2, Hanqing Jasinda Lee3, Kim Peng Mitchell Lai3, Sangyong Jung2, Fu Yu2, Malini Olivo2, John Gigg1, and Joanes Grandjean4
1Faculty of biology, medicine and health, University of Manchester, manchester, United Kingdom, 2Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, Singapore, 3Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4Department of Radiology and Nuclear Medicine & Donders Institute for Brain, Cognition, and Behaviour, Donders Institute, Radboud University Medical Centre, Nijmegen, Netherlands

Alzheimer’s disease (AD) is characterised by progressive memory loss, neurodegeneration and brain atrophy. Intra- and inter-regional connectivity across the brain is affected in AD, probably due to the aberrant accumulation of toxicity. The entorhinal cortex is a key region involved in the early stages of AD. We report synaptic connectivity increase in the 3xTg mouse model, by means of electrophysiological recordings in AD-susceptible brain regions, following stimulation of the entorhinal cortex, in vivo. Further, we demonstrate loss of functional connectivity with resting-state fMRI in AD-vulnerable brain regions, which converts into increased response during optogenetics photostimulation of the entorhinal cortex.

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