Alzheimer’s disease (AD) is characterised by progressive memory loss, neurodegeneration and brain atrophy. Intra- and inter-regional connectivity across the brain is affected in AD, probably due to the aberrant accumulation of toxicity. The entorhinal cortex is a key region involved in the early stages of AD. We report synaptic connectivity increase in the 3xTg mouse model, by means of electrophysiological recordings in AD-susceptible brain regions, following stimulation of the entorhinal cortex, in vivo. Further, we demonstrate loss of functional connectivity with resting-state fMRI in AD-vulnerable brain regions, which converts into increased response during optogenetics photostimulation of the entorhinal cortex.
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