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Abstract #1353

Functional MRI investigation of Optogenetically-evoked Spindle-like Neural Activity and Memory Consolidation

Xunda Wang1,2, Alex T. L. Leong1,2, Shawn Zheng kai Tan3, Teng Ma1,2, Pek-Lan Khong4, Lee-Wei Lim3, and Ed Xuekui Wu1,2,3,4
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong, 3School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 4Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Spindle is one of the most critical brain oscillatory activities that has been shown to mediate sensory transmission and memory consolidation. However, where and how spindle-related activities are distributed at the systems level and their brain-wide propagation targets remain elusive. In this study, we demonstrate the first integrative view of the causal recruitment of brain-wide networks by thalamo-cortically initiated spindle-related activities in a temporal-frequency specific manner and verified its role in facilitating memory consolidation.

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