Abstract #1353

Functional MRI investigation of Optogenetically-evoked Spindle-like Neural Activity and Memory Consolidation

Xunda Wang^1,2, Alex T. L. Leong^1,2, Shawn Zheng kai Tan³, Teng Ma^1,2, Pek-Lan Khong⁴, Lee-Wei Lim³, and Ed Xuekui Wu^1,2,3,4

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong, ³School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Spindle is one of the most critical brain oscillatory activities that has been shown to mediate sensory transmission and memory consolidation. However, where and how spindle-related activities are distributed at the systems level and their brain-wide propagation targets remain elusive. In this study, we demonstrate the first integrative view of the causal recruitment of brain-wide networks by thalamo-cortically initiated spindle-related activities in a temporal-frequency specific manner and verified its role in facilitating memory consolidation.

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