Abstract #1354

Distinguish hemodynamic responses at the white matter tract from the laminar-specific gray matter fMRI signal with line-scanning fMRI

Sangcheon Choi^1,2, Hang Zeng^1,2, Bharat Biswal³, Bruce R. Rosen⁴, and Xin Yu^1,4

¹Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, Tuebingen, Germany, ³Department of Biomedical Engineering, NJIT, Newark, NJ, United States, ⁴MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

We applied line-scanning fMRI to investigate evoked hemodynamic responses in both laminar-specific gray matter (GM) and white matter (WM) in rats. Based on the WM-specific cross-correlation lag time to the laminar-specific fMRI signal, distinct WM hemodynamic responses were characterized across animals, showing a biphasic HRF with earlier lag times and a monophasic HRF with later lag times. Also, the lag-time dependent HRFs were detected in the subcortical area under the WM. Elucidating neurovascular coupling characteristics of distinct WM hemodynamic responses may help understand the progression of WM-related diseases, e.g. multiple sclerosis (MS) or small vessel disease (SVD).

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