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Abstract #1537

Investigation of the Global Volumetry and Relaxometry of the Brain in Parkinson's Disease using Synthetic MRI

Na Lu1,2, Chunmei Li1, Shuhua Li3, Pu-Yeh Wu4, Wen Su3, Haibo Chen3, and Min Chen1,2
1Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China, 2Graduate School of Peking Union Medical College, Beijing, China, 3Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing, China, 4GE Healthcare, MR Research China, Beijing, China

This study revealed both the brain volumetric and relaxometric characteristics from synthetic MRI technique in Parkinson's disease (PD). Significantly differences were found in fraction of gray matter (GM), white matter (WM) and myelin. We also observed significantly differences in WM T1 value, GM and CSF proton density value. Hence Synthetic MRI might be a quantitative tool for clinical diagnosis of PD.

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