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Abstract #1538

Relationship between Free Water and Neuroinflammation/Neurodegeneration Markers in HIV Before and After Combination Antiretroviral Therapy

Md Nasir Uddin1, Abrar Faiyaz2, Yuchuan Zhuang2, Madalina Tivarus3,4, Jianhui Zhong4,5, Maxime Descoteaux6, and Giovanni Schifitto4,7
1Department of Neurology, University of Rochester, Rochester, NY, United States, 2Electrical & Computer Engineering, University of Rochester, Rochester, NY, United States, 3Radiology, University of Rochester, Rochester, NY, United States, 4Imaging Sciences, University of Rochester, Rochester, NY, United States, 5Physics, University of Rochester, Rochester, NY, United States, 6Computer Science, University of Sherbrooke, Sherbrooke, QC, Canada, 7Neurology, University of Rochester, Rochester, NY, United States

Free water (FW) index, a measure of extracellular non-flowing water in the brain parenchyma, can be sensitive to neuroinflammation. We examine the relationship between the FW index and putative markers of neuroinflammation in cART-naïve participants before and after 12 weeks of the treatment. We found that FW index correlated with neuroinflammation markers in HIV+ participants for some GM and WM structures at baseline while this correlation diminished after 12 weeks of cART treatment in some WM structures for NfL.

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