Abstract #1538

Relationship between Free Water and Neuroinflammation/Neurodegeneration Markers in HIV Before and After Combination Antiretroviral Therapy

Md Nasir Uddin¹, Abrar Faiyaz², Yuchuan Zhuang², Madalina Tivarus^3,4, Jianhui Zhong^4,5, Maxime Descoteaux⁶, and Giovanni Schifitto^4,7

¹Department of Neurology, University of Rochester, Rochester, NY, United States, ²Electrical & Computer Engineering, University of Rochester, Rochester, NY, United States, ³Radiology, University of Rochester, Rochester, NY, United States, ⁴Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁵Physics, University of Rochester, Rochester, NY, United States, ⁶Computer Science, University of Sherbrooke, Sherbrooke, QC, Canada, ⁷Neurology, University of Rochester, Rochester, NY, United States

Free water (FW) index, a measure of extracellular non-flowing water in the brain parenchyma, can be sensitive to neuroinflammation. We examine the relationship between the FW index and putative markers of neuroinflammation in cART-naïve participants before and after 12 weeks of the treatment. We found that FW index correlated with neuroinflammation markers in HIV+ participants for some GM and WM structures at baseline while this correlation diminished after 12 weeks of cART treatment in some WM structures for NfL.

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